Zoetis
(oxytetracycline hydrochloride)
Antibiotic
Ophthalmic Ointment
with Polymyxin B Sulfate
DESCRIPTION: Terramycin
(oxytetracycline HCl) is an antibiotic, bright yellow in color,
possessing potent antimicrobial activity. It is one of the most
versatile of the broad-spectrum antibiotics, and is effective in the
treatment of infections due to gram-positive and gram-negative bacteria,
both aerobic and anaerobic, spirochetes, rickettsiae, and certain of
the larger viruses.
Polymyxin B sulfate is one of a group of related antibiotics derived from Bacillus polymyxa. The polymyxins are rapidly bactericidal, this action being exclusively against gram-negative bacteria.
The broad-spectrum effectiveness of Terramycin against
both gram-positive and gram-negative organisms is enhanced by the
particular effectiveness of polymyxin B against infections associated
with gram-negative organisms, especially those due to Pseudomonas aeruginosa,
where polymyxin B is the antibiotic of choice. In addition, there is
evidence to indicate that polymyxin B sulfate possesses some antifungal
activity. The combined antibacterial effect of Terramycin plus polymyxin
is at least additive and, in many instances, an actual synergistic
action is obtained.
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate
is a suspension of oxytetracycline hydrochloride and polymyxin B sulfate
in a special petrolatum base. Each gram of ointment contains
oxytetracycline HCl equivalent to 5 mg of oxytetracycline and 10,000
units of polymyxin B as the sulfate.
INDICATIONS AND USAGE: Terramycin
Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the
prophylaxis and local treatment of superficial ocular infections due to
oxytetracycline and polymyxin-sensitive organisms, including infections
due to streptococci, rickettsiae, E. coli, and A. aerogenes,
such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis
in dogs, cats, cattle, sheep, and horses; ocular infections due to
secondary bacterial complications of distemper in dogs, and bacterial
inflammatory conditions which may occur secondary to other infectious
diseases in the above species.
PRECAUTIONS: Allergic reactions may occasionally occur. Treatment should be discontinued if reactions are severe.
Note: The use of oxytetracycline and
other antibiotics may result in an overgrowth of resistant organisms
such as Monilia, staphylococci, and other species of bacteria. If new
infections due to nonsensitive bacteria or fungi appear during therapy,
appropriate measures should be taken.
DOSAGE AND ADMINISTRATION: Terramycin Ophthalmic Ointment with Polymyxin B Sulfate should be administered topically to the eye 2-4 times daily.
RECOMMENDED STORAGE: Store at controlled room temperature between 20° to 25°C (68° to 77°F), with excursions between 15° to 30°C (59° to 86°F).
HOW SUPPLIED: 1/8-oz (3.5-g) tube
For Animal Use Only
Restricted Drug (California)-Use Only As Directed
Not for Human Use
NADA#8-763, Approved by FDA
Distributed by: Zoetis Inc., Kalamazoo, MI 49007
Made in Switzerland
Revised: June 2013
23288601
NAC No.: 3690179.3