Palladia Tablets

How to Order Prescriptions

---

Description

Palladia Tablets are indicated for the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs only. This medication uses toceranic phosphate to combat the effects of these recurrent tumors and works on both tumors with and without regional lymph node involvement. Palladia can also be used as an alternative to chemotherapy for other various types of tumors, including melanomas, thyroid carcinomas, and more.

Dosage and Administration

Always refer to Client Information Sheet with prescription and discuss with your veterinarian. Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day (see Table 1 in Product Label Tab). Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of PALLADIA for up to two weeks) may be utilized, if needed, to manage adverse reactions (see Table 2 as well as Warnings and Precautions). Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter. PALLADIA may be administered with or without food. Do not split tablets. See Product Label Tab for more detailed information.

 

Dosage Table

Dog Body Weight		Number Of Tablets
Pounds Kilograms  11.0 - 11.8 5.0 - 5.3 11.9 - 15.2 5.4 - 6.9 15.3 - 18.5 7.0 - 8.4 18.6 - 22.0 8.5 - 10.0 22.1 - 25.4 10.1 - 11.5 25.5 - 28.7 11.6 - 13.0 28.8 - 32.2 13.1 - 14.6 32.3 - 35.5 14.7 - 16.1 35.6 - 38.8 16.2 - 17.6 38.9 - 42.3 17.7 - 19.2 42.4 - 45.6 19.3 - 20.7 45.7 - 50.7 20.8 - 23.0 50.8 - 59.3 23.1 - 26.9 59.4 - 65.9 27.0 - 29.9 66.0 - 71.2 30.0 - 32. 3 71.3 - 76.3 32.4 - 34.6 76.4 - 79.6 34.7 - 36.1 79.7 - 84.7 36.2 - 38.4 84.8 - 94.8 38.5 - 43.0 94.9 -105.0 43.1 - 47.6 105.1 - 110.0 47.7 - 49.9 110.1 - 113.5 50.0 -51.5 113.6 - 118.6 51.6 - 53.8 118.7 - 128.8 53.9 - 58.4 128.9 - 138.9 58.5 - 63.0 139.0 - 144.0 63.1 - 65.3 144.1 - 157.6 65.4 - 71.5 157.7 - 173.1 71.6 - 78.5 173.2 - 177.9 78.6 - 80.7 178.0 - 191.6 80.8 - 86.9 191.7 - 220.5 87.0 - 100.0	Dose 15 mg 20 mg 25 mg 30 mg 35 mg 40 mg 45 mg 50 mg 55 mg 60 mg 65 mg 70 mg 80 mg 95 mg 100 mg 110 mg 115 mg 120 mg 130 mg 150 mg 160 mg 165 mg 170 mg 180 mg 200 mg 210 mg 215 mg 250 mg 260 mg 265 mg 300 mg	10 mg 15 mg 50 mg   1   2     1 1     2   2 1   1 2     3       1 1 3   1   1   1 1 2   1   2 1   3 1     2 1   2   1 2 2   2   2 2     3 1   3   1 3 2   3   2 3   4 1 4   1 4   5 1   5   1 5     6

Storage Directions

Store at controlled room temperature 20° to 25° C (68° to 77° F). Keep away from children and pets.

 

Contraindications

Do not use in dogs used for breeding, or for pregnant or lactating bitches (see Clinical Pharmacology).

Warnings

Palladia may cause vascular dysfunction which can lead to edema and thromboembolism, including pulmonary thromboembolism. Discontinue drug until clinical signs and clinical pathology have normalized. To assure vasculature homeostasis, wait at least 3 days after stopping drug before performing surgery (see Adverse Reactions). Serious and sometimes fatal gastrointestinal complications including gastrointestinal perforation have occurred rarely in dogs treated with PALLADIA (see Adverse Reactions). If gastrointestinal ulceration is suspected, stop drug administration and treat appropriately.

Human Warnings

NOT FOR USE IN HUMANS. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. Children should not come in contact with PALLADIA. Keep children away from feces, urine, or vomit of treated dogs. To avoid exposure to drug, wash hands with soap and water after administering PALLADIA and wear protective gloves to prevent direct contact with feces, urine, vomit, and broken or moistened PALLADIA tablets. Place all waste materials in a plastic bag and seal before general disposal. If eyes are accidentally exposed to the drug, rinse eyes with water immediately. In case of accidental ingestion by a person, seek medical advice immediately, show the package insert or label to the physician. Gastrointestinal discomfort such as vomiting or diarrhea may occur if this drug is accidentally ingested. Pregnant women, women who may become pregnant, or nursing mothers should pay special attention to these handling precautions. (See handling instructions above.) PALLADIA, like other drugs in its class, prevents the formation of new blood vessels in tumors. In a similar manner, PALLADIA may affect blood vessel formation in the developing fetus and may harm an unborn baby (cause birth defects). For pregnant women, accidental ingestion of PALLADIA may have adverse effects on pregnancy.

RX required for this item. Click here for our full Prescription Policy and Form

---

Palladia Tablets

• Antineoplastic
• For oral use in dogs only
• Antiproliferative and antiandiogenic agent used to treat Patnaik grade II or III, cutaneous mast cell tumors in dogs.
• This medication uses toceranic phosphate to combat the effects of these recurrent tumors and works on both tumors with and without regional lymph node involvement.
• Can also be used as an alternative to chemotherapy for other various types of tumors, including melanomas, thyroid carcinomas, and more.

Dosage and Administration

• Always refer to Client Information Sheet with prescription and discuss with your veterinarian.
• Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day (see Table 1 in Product Label Tab).
• Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of PALLADIA for up to two weeks) may be utilized, if needed, to manage adverse reactions (see Table 2 as well as Warnings and Precautions).
• Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter.
• PALLADIA may be administered with or without food.
• Do not split tablets.

See Product Label Tab for more detailed information.