Sertraline Hydrochloride

Potential Side Effects

• tremors
• poor appetite
• lethargy
• Itchiness
• diarrhea
• vomiting
• anxiety
• panting
• sleep disturbances
• agitation
• dry skin 
• loss of appetite can be significant, but it is usually temporary.

*Rarely, sertraline may increase aggression in dogs. If this occurs, the medication should be stopped immediately and a veterinarian should be consulted.

Precautions

To be used cautiously in animals with a history of blood disorders or seizures or pets with a known allergy or hypersensitivity to Sertraline. If any of these side effects develop during treatment, the drug should be stopped and a veterinarian should be consulted. The drug should only be used if absolutely necessary in geriatric animals and in those with liver disease. It is not for use in pregnant or lactating animals.

Possible Drug Interactions

•  warfarin,
• digoxin,
• phenylbutazone,
• cisapride,
• diazepam,
• buspirone,
• tricyclic antidepressants,
• cimetidine,
• cyproheptadine,
• metoclopramide,
• *The drug should not be taken within 5 weeks of taking a MOI or monoamine oxidase inhibitor due to the potential for a severe or fatal reaction. It is important to disclose all medications and supplements being taken before beginning treatment with sertraline.

Overdose of sertraline can be serious or fatal and may cause diarrhea, lethargy, fever, tremors, drooling, vomiting, muscle rigidity, agitation, increased heart rate, seizures, vocalization, and coma. Any known or suspected overdose should be reported to a veterinarian right away.

Instructions

Sertraline should be stored in its original packaging, out of the reach of children and animals, and at room temperature. It should be kept away from light and heat. It is important to follow your Veterinarian's prescription instructions for your pet

• In dogs, the typical dose of sertraline is 1.25 to 2.5 mg/lb (2.5 to 5.0 mg/kg) by mouth once daily.
• In cats, the typical dose is 0.5 to 2.0 mg/lb (1.0 to 4.0 mg/kg) by mouth once daily.